Exosomes in Cosmetic Medicine
What are Exosomes?
Exosomes are tiny vesicles (tiny sacs that transport material within and outside the cell) secreted by various cells in the body, including stem cells, biological fluids as well as skin cells. These nanosized particles play a crucial role in cell-to-cell communication and are packed with bioactive molecules such as proteins, lipids, and nucleic acids. These tiny molecules carry genetic material from their cell of origin.
These tiny extracellular vesicles, also known as exosomes, are secreted by cells in the body and can be isolated and extracted using various methods. The choice of extraction method depends on the source of exosomes (e.g., cell culture, biological fluids) and the specific research or clinical application.
In recent years, exosomes have gained significant attention in the field of cosmetic medicine due to their potential in skin rejuvenation, anti-aging, and overall skin health improvement.
What makes exosomes so appealing for cosmetic medicine?
Exosomes are attractive in cosmetic medicine for several reasons:
- Natural Regeneration: Exosomes contain growth factors and other bioactive substances that promote cell regeneration and tissue repair, helping to rejuvenate the skin naturally.
- Minimal Risk: Since exosomes are derived from the patient’s own cells or donor cells, there is minimal risk of allergic reactions or rejection, making them a safe option.
- Non-Invasive: Exosome-based treatments are typically non-invasive and can be administered through topical applications, injections, or microneedling.
- Customizable: Exosomes can be isolated from various cell sources, allowing for customized treatments tailored to the patient’s specific needs.
How do exosomes work in cosmetic treatments?
Exosomes work by delivering their cargo of bioactive molecules to target cells. When used in cosmetic medicine, exosomes can:
- Stimulate collagen production, leading to improved skin elasticity and reduced wrinkles.
- Enhance the skin’s ability to repair itself, resulting in a more youthful appearance.
- Promote angiogenesis (the formation of new blood vessels), which can improve skin texture and color.
- Reduce inflammation and oxidative stress, addressing common skin issues.
What are some common cosmetic procedures involving exosomes?
What are some common cosmetic procedures involving exosomes?
- Topical Exosome Serums: These serums can be applied directly to the skin to improve overall skin health and appearance.
- Exosome Injections: Exosomes can be injected into targeted areas, such as the face or neck, to enhance skin rejuvenation. Currently this is not approved by the FDA or Health Canada.
- Microneedling with Exosomes: Microneedling is often combined with exosome application to maximize the absorption of exosome-derived growth factors and proteins.
- Post treatment with exosomes: Exosomes can be applied topically post RF microneedling, post fractionated Erbium or CO2 laser as well as post PRP with microneedling.
Are there any side effects or risks associated with exosome-based treatments?
Exosome-based treatments are generally considered safe with minimal risks. Since they are derived from the patient’s own cells or donor cells, allergic reactions and rejection are rare. However, as with any medical procedure, there can be some potential side effects, such as swelling, redness, or bruising, which are usually mild and temporary.
Where are exosomes derived from?
Exosomes can be derived from donor cells either from adipose cells (fat cells), bone marrow, or Wharton’s jelly from the umbilical cord. (a gelatinous substance whose function is to insulate the umbilical cord in the womb)
Other sources of exosomes include blood plasma, urine, saliva, cerebrospinal fluid, breast milk and various cell cultures.
Depending on the tissue that the exosomes are derived from, they can provide insight into different organs in the body therefore allowing researchers to study different conditions and how exosomes can deliver different messages to the cells involved.
There are multiple methods of extraction of exosomes from the stem cells to enhance purity and yield.
One very interesting source of exosomes are exosomes derived from one’s own cells which can be cryogenically banked in a stem cell bank. This is also known as autologous (i.e., from your own body) stem cells or exosomes.
One example of autologous exosomes is that of Acorn technologies based out of University of Toronto which uses your own hair follicles to extract your own exosomes for use in tissue regeneration such as skin and scalp for hair regrowth.!.
How long do the results of exosome treatments last?
The longevity of results can vary depending on factors such as the patient’s age, skin condition, and the specific treatment used. Many patients report noticeable improvements in skin texture and appearance that can last several months to over a year. To maintain the results, periodic touch-up treatments may be recommended.
Your practitioner will discuss this with you.
What are BENEV exosomes?
Benev regenerative complex exosomes are derived from mesenchymal stem cells found in human adipose tissue (or fat cells). Each treatment vial contains 5 billion stem cells derived exosomes, 15 potent growth factors, peptides, coenzymes, 5 minerals, 19 amino acids and 2 vitamins.
Mesenchymal cells (MSC) are also known as medicinal signaling cells that are multipotent stromal cells that can differentiate into a variety of cell types including bone cells, cartilage cell and fats cells.
BENEV Exosomes:
- Source: BENEV Exosomes are typically derived from mesenchymal stem cells (MSCs) obtained human adipose cells.
- Composition: BENEV Exosomes derived from the MSCs found in the adipocyte (fat cell) which are known for their regenerative properties. They contain a range of bioactive molecules, including growth factors, cytokines, and extracellular vesicles.
- Benefits:
- Skin Rejuvenation: BENEV Exosomes are often used in cosmetic medicine for skin rejuvenation, promoting collagen production, reducing wrinkles, and improving overall skin texture.
- Anti-Inflammatory: They have anti-inflammatory properties that can help calm and soothe irritated skin.
- Wound Healing: BENEV Exosomes may contribute to enhanced wound healing and tissue repair.
- Hair regrowth and restoration: Benev exosomes can contribute to improved scalp and hair regrowth.
- Safety: BENEV Exosomes are typically considered safe, as they are rigorously processed and screened for potential contaminants. However, individual responses can vary.
Umbilical Cord Exosomes:
- Source: Umbilical cord exosomes, in a broader sense, refer to exosomes obtained from umbilical cord tissues, including Wharton’s jelly, but can also encompass exosomes derived from other parts of the cord.
- Composition: Similar to BENEV Exosomes, umbilical cord exosomes contain exosomes obtained from various cell types within the umbilical cord. These exosomes also carry a mix of bioactive molecules, which can vary depending on the source.
- Benefits:
- Stem Cell Properties: Umbilical cord-derived exosomes are associated with potent regenerative and stem cell-like properties, which may contribute to enhanced tissue repair.
- Potential Immune Modulation: Some research suggests that umbilical cord exosomes may have immunomodulatory effects, possibly reducing inflammation and supporting tissue healing.
- Safety: Umbilical cord exosomes are typically produced under strict quality control measures to ensure safety, but like any medical product, there can be potential risks if not properly processed or administered.
Acorn Biolabs exosomes
Non-invasive stem cell extraction
Preserving your cells for personalized regenerative medicine – medical & cosmetic
Acorn Biolabs exosomes are derived from your own hair follicle. These exosomes are autologous meaning that the donor is oneself!
50 of your hair follicles are extracted from the sides and back of your head and sent for analysis to ensure that you have enough live cells to be used in the future.
These cells are cryogenically preserved in a cell bank in Toronto General Hospital so that they can be preserved for future use.
Acorn Biolabs cell banking involves collecting and storing your own follicle cells, which are specialized cells that can provide therapeutic benefit in the future. Cell banking freezes your cells to preserve their current state and bypass the effects of aging.
Since these exosomes extracted your own cells, they are the safest source of exosomes.
Because these follicles are sourced from the patient, when the time comes time for the patient to use their cells for regenerative medicine, there won’t be any risk of rejection or immune complications.
Individual Response:
The effectiveness and safety of exosome treatments can vary from person to person. Personalized consultation with a medical professional is crucial to determine the most suitable option and manage expectations.
Conclusion
Exosomes have emerged as promising tools in the field of cosmetic medicine, offering natural and effective ways to enhance skin health and appearance. Their ability to stimulate cellular regeneration, promote collagen production, and reduce inflammation has made them valuable components in various cosmetic procedures. As research and technology continue to advance, exosome-based treatments are likely to become even more refined and widespread in the world of cosmetic medicine.